Functional analysis of murine uterine natural killer cells genetically devoid of oestrogen receptors
AM Borzychowski, S Chantakru, K Minhas… - Placenta, 2003 - Elsevier
Uterine Natural Killer (uNK) cell differentiation in vivo requires oestrogen (E) priming prior to
progesterone (P). Hybridomas between uNK precursor and SP2/0 cells express message for
E receptor (ER) α but nor PR. However, mature, rodent and human uNK cells lack these
receptors. To functionally assess requirements for uNK cell expression of ERα or ERβ during
precursor differentiation, marrow was transplanted from either ERαo/o (αERKO) or ERβo/o
(βERKO) mice into alymphoid RAG-2o/o/γco/o females. Recipients were mated and their …
progesterone (P). Hybridomas between uNK precursor and SP2/0 cells express message for
E receptor (ER) α but nor PR. However, mature, rodent and human uNK cells lack these
receptors. To functionally assess requirements for uNK cell expression of ERα or ERβ during
precursor differentiation, marrow was transplanted from either ERαo/o (αERKO) or ERβo/o
(βERKO) mice into alymphoid RAG-2o/o/γco/o females. Recipients were mated and their …
