Pregnancy blockade by indomethacin, an inhibitor of prostaglandin synthesis: its reversal by prostaglandins and progesterone in mice
IF Lau, SK Saksena, MC Chang - Prostaglandins, 1973 - Elsevier
Results in the present study clearly indicate that subcutaneous injections of indomethacin
(150 μg/day) to the pregnant mice on days 1, 2, 3 and 4 of pregnancy terminate pregnancy
in 100 percent of the animals. A single injection of 225 μg/day/mouse on day 2 of pregnancy
results in 100 percent inhibition of pregnancy. Since this dose of indomethacin was not as
effective when given either on day 1, 3 or 4 of pregnancy, it is likely that indomethacin acts
through a tubal disturbances by suppressing prostaglandins for the retention of the ova …
(150 μg/day) to the pregnant mice on days 1, 2, 3 and 4 of pregnancy terminate pregnancy
in 100 percent of the animals. A single injection of 225 μg/day/mouse on day 2 of pregnancy
results in 100 percent inhibition of pregnancy. Since this dose of indomethacin was not as
effective when given either on day 1, 3 or 4 of pregnancy, it is likely that indomethacin acts
through a tubal disturbances by suppressing prostaglandins for the retention of the ova …
