Osteoarthritis (OA) is a painful, disabling condition that arises from damage to cartilage,
synovium, subchondral bone, and other joint structures. An estimated 300 million people
worldwide have OA, 1 including 30 million individuals in the United States, 2 of whom more
than 14 million have symptomatic, radiographically documented knee OA. 3 Despite the
enormous prevalence, cost, and disability associated with OA, no treatments are available to
slow or reverse the inexorable destruction of joint structures that underlie the pain and …